The structure of inducing factors for virginiamycin production in Streptomyces virginiae.
نویسندگان
چکیده
منابع مشابه
The structure of inducing factors for virginiamycin production in Streptomyces virginiae.
Virginiamycin inducing factors (inducing material or inducing factor) of Streptomyces virginiae were isolated from the culture broth of this microbe and separated into three closely related compounds. They were named virginiae butanolides A, B and C and their structures were determined as 2-(1'-hydroxy-5'-methylhexyl)-3-(hydroxymethyl)butanolide (6), 2-(1'-hydroxy-4'-methylhexyl)-3-(hydroxymeth...
متن کاملIdentification of binding protein of virginiae butanolide C, an autoregulator in virginiamycin production, from Streptomyces virginiae.
In Streptomyces virginiae, production of virginiamycin is triggered by signal molecules named virginiae butanolide A, B or C (VB-A, B or C: Yamada, Y. et al. J. Antibiotics 40: 496-504, 1987). We have found a specific VB-C binding protein from S. virginiae, and characterized it by using a tritium-labeled VB-C analogue as a ligand. By equilibrium dialysis in the absence and presence of radio-ine...
متن کاملCharacterization of biosynthetic gene cluster for the production of virginiamycin M, a streptogramin type A antibiotic, in Streptomyces virginiae.
Virginiamycin M (VM) of Streptomyces virginiae is a hybrid polyketide-peptide antibiotic with peptide antibiotic virginiamycin S (VS) as its synergistic counterpart. VM and VS belong to the Streptogramin family, which is characterized by strong synergistic antibacterial activity, and their water-soluble derivatives are a new therapeutic option for combating vancomycin-resistant Gram-positive ba...
متن کاملTransfection in Streptomyces virginiae
Until now, transformation with linear DNA has not been demonstrated in Streptomycetes, although it has been established in a thermophilic Actinomyces species, Thermoactinomyces vulgaris (Hopwood & Wright, 1972). The main tool used in Streptomycete genetics is conjugation (Hopwood, 1967). In the wake of a genetic map for Streptomyces coelicolor, maps for other strains were constructed by means o...
متن کاملfaciliting lexical access for the fluent production of speech
the hypothesis is that recent and frequent exposure to lexical items leads to a more fluent production of speech in terms of rate of speech. to test the hypothesis,a one-way anova experimental design was carried out. 24 sednior students of efl participated in a one-way interview test. data analyses revealed that those who were exposed frequently to the lexical items over a week prior to inter...
15 صفحه اولذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1987
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.40.496